Nanopharmaceutics Inc. Announces Initiation of Clinical Study of Triapine + Radiation for Glioblastoma or Astrocytoma

Initiation of Clinical Study Testing the Addition of an Anti-Cancer Drug, Triapine®, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma

TRON Group Inc. (OTCMKTS:TGRP)

ALACHUA, FL, UNITED STATES, April 1, 2025 /EINPresswire.com/ -- Nanopharmaceutics, Inc., a clinical-stage pharmaceutical development company, announced initiation a Phase 1 clinical study sponsored by the National Cancer Institute, part of the National Institutes of Health, titled “Testing the Addition of an Anti-Cancer Drug, Triapine^®, to the Usual Radiation Therapy for Recurrent Glioblastoma or Astrocytoma” (NCI protocol 10669, ClinicalTrials.gov Identifier: NCT06860594). The primary objective of the phase 1 study will be to identify the safety and maximally tolerated dose (MTD) of oral Triapine^® used in combination with radiation therapy for patients with recurrent glioblastoma (GBM) or astrocytoma. The Principal Investigator is Stephanie M Yoon, City of Hope Comprehensive Cancer Center Lead Academic Organization, and the study will recruit 30 patients. The study will be performed under a Cooperative Research and Development Agreement (CRADA) between NCI and Nanopharmaceutics and conducted by the NCI funded Experimental Therapeutics Clinical Trials Network (ETCTN).

This phase I trial tests the safety, side effects, and best dose of Triapine^® in combination with radiation therapy in treating patients with glioblastoma or astrocytoma that has come back after a period of improvement (recurrent). Triapine^® may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Radiation therapy uses high energy x-rays, particles, or radioactive seeds to kill cancer cells and shrink tumors. Giving Triapine^® in combination with radiation therapy may be safe, tolerable, and/or effective in treating patients with recurrent glioblastoma or astrocytoma.

About Triapine^®

Triapine^® is s synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity being studied in the treatment of cancer. It is a type of ribonucleotide reductase inhibitor. Also called 3-aminopyridine-2-carboxaldehyde thiosemicarbazone and 3-AP, Triapine^® inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis.

About Nanopharmaceutics, Inc.

Nanopharmaceutics, Inc. is a clinical-stage specialty pharmaceutical company developing oral, topical, and injectable products for cancer, central nervous system (CNS) disorders, and infectious diseases. Leveraging its expertise in nanoparticle and fine-particle formulations, which can specifically be used to improve hard-to-deliver Biopharmaceutics Classification System (BCS) category II and IV drugs, Nanopharmaceutics is focused on formulation development aimed at improving drug absorption and stability. Nanopharmaceutics is a subsidiary of TRON Group Inc. (OTC:TGRP).

James D Talton
Nanopharmaceutics, Inc.
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