First-in-class antibiotic is safe in rats
The research, which was undertaken jointly by Boulos & Cooper Pharmaceuticals, US-based Product Safety Labs and ToxStrategies Inc., and Flinders University, has shown no mortalities in this study and no-Ramizol®-related clinical observations or side-effects. Additionally, there were no changes in mean body weight, body weight gain, food consumption or food efficiency in male and female rats attributed to the intake of the drug.
Chief Executive Officer of Boulos & Cooper Pharmaceuticals, Dr Ramiz Boulos, said "We are extremely pleased with these results for two reason. Firstly, we were able to dose rats at a very high dose, equivalent to 150 mg/mL. This level of solubility provides Ramizol® with an edge over its competition where solubility does not limit the need to administer high doses to target drug resistant bacteria. Secondly, the high level of tolerance of Ramizol® in rats has de-risked the development of this asset significantly for our first-in-man clinical trials and has given us the confidence to pursue its development”.
Ramiz Boulos
Boulos & Cooper Pharmaceuticals Pty Ltd
+61 431 150 538
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